Radiation Biology Team

Laboratory Head
Tomoko ABED.Agr.
  • 1989年東北大学大学院農学研究科農学専攻修了
    東北大学遺伝生態研究センター 遺伝子多様性研究部門 日本学術振興会特別研究員
  • 1990年理化学研究所 薬剤作用研究室 基礎科学特別研究員
  • 1991年同 研究員
  • 1993年同 植物機能研究室 研究員
  • 2006年同 仁科加速器科学研究センター加速器応用研究グループ生物照射チ−ム副チームリーダー
  • 2008年同 加速器応用研究室生物照射チーム チームリーダー
  • 2010年同 加速器応用研究室 室長


Research Areas

The radiation biology team carries out on studies various biological effects of fast heavy ions. It is also involved in the development of a new technique to breed plants by heavy-ion irradiation. Fast heavy ions can cause dense and localized ionization of matter along their tracks, in contrast to photons X-rays and γ-rays, which cause randomly distributed isolated ionization. The localized, dense ionization can cause double-strand DNA breaks in cells induced by; these breaks are not easily repaired, and they result in more effective mutation than that single-strand DNA breaks. A unique feature of our experimental facility at the RIKEN Ring Cyclotron (RRC) is that living bodies in helps them the atmosphere or bottles can be irradiated since the delivered heavy-ion beams have sufficiently high energy that penetrate matter to a significant depth. The radiation biology team utilizes a dedicated beam line (E5B) of the RRC to irradiate microbes, plants, and animals with a wide variety of ion beams, ranging from C to Fe. The research subjects include physiological studies on DNA repair, genome analyses of mutation, and mutation breeding of plants by heavy-ion irradiation. Some new cultivars have already been introduced in the market.

Asagao Club (Japanese only)

Research Subject

  1. Biological effects caused by heavy-ion irradiation
  2. Ion-beam breeding and genome analysis
  3. Innovative applications of heavy-ion beams

List of Selected Publications

  1. Izumi M, Mizuno T, Yanagi K, Sugimura K, Okumura K, Imamoto N, Abe T, and Hanaoka F.:
    "The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing"
    J. Biol. Chem. doi: 10.1074/jbc.M117.779371 (2017)
  2. Ishii K., Kazama Y., Morita R., Hirano T., Ikeda T., Usuda S., Hayashi Y., Ohbu S., Ikeda R., Nakamura Y., Abe T.:
    "Linear Energy Transfer-Dependent Change in Rice Gene Expression Profile after Heavy-Ion Beam Irradiation"
    PLOS ONE 11(7), e0160061 (2016)
  3. Ikeda T., Kojima T., Natsume Y., Kimura J., Abe T.:
    "Stable transmission of slow highly charged ions through tapered glass capillary with active discharging method for sub-micron sized beams"
    Applied Physics Letters 109, Article No. 133501 (2016)
  4. Yamada K., Suzuki H., Takeuchi T., Kazama Y., Mitra S., Abe T., Goda K., Suzuki K., Iwata O.:
    "Efficient selective breeding of live oil-rich Euglena gracilis with fliorescence-actived cell sorting"
    Sci.Rep.6, Article No. 26327 (2016)
  5. Kato M., Masamura N., Shono J., Okamoto D., Abe T., Imai S.:
    "Production and characterization of tearless and non-pungent onion"
    Sci.Rep.6, Article No. 23779 (2016)
  6. Kazama Y., Ishii K., Aonuma W., Ikeda T., Kawamoto H., Koizumi A., D. A. Filatov, M. Chibalina, R. Bergero, D. Charlesworth, Abe T., Kawano S.:
    "A new physical mapping approach refines the sex-determining gene positions on the Silene latifolia Y-chromosome"
    Sci.Rep. 6, Article No.18917 (2016)
  7. Katano M., Takahashi K., Hirano T., Kazama Y., Abe T., Tsukaya H., Ferjani A.:
    "Suppressor Screen and Phenotype Analyses Revealed an Emerging Role of the Monofunctional Peroxisomal Enoyl-CoA Hydratase 2 in Compensated Cell Enlargement"
    Front. Plant Sci. 7, Article 132 (2016)
  8. Morita R., Nakagawa M., Takehisa H., Hayashi Y., Ichida H., Usuda S., Ichinose K., Abe H., Shirakawa Y., Sato T., Fujiwara T. M., Itoh D.R., Abe T.:
    "Heavy-ion beam mutagenesis identified an essential gene for chloroplast development under cold stress conditions during both early growth and tillering stages in rice"
    Biosci. Biotechnol. Biochem. 81(2), .271-282 (2016)
  9. Hirano T, Kazama Y, Ishii K, Ohbu S, Shirakawa Y, and Abe T.:
    "Comprehensive identification of mutations induced by heavy‐ion beam irradiation in Arabidopsis thaliana"
    Plant J. 82: 93-104 (2015)
  10. Abe T., Kazama Y., Hirano T.:
    "Ion beam breeding and gene discovery for function analyses using mutants"
    Nuclear Physics News 25, 30-35 (2015)


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